chronic obstructive pulmonary disease, stable, moderate to severe
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2011 Mar 24;364(12):1093-103 Randomized Controlled Trial, Multicenter Study
IN chronic obstructive pulmonary disease, stable, moderate to severe The Use of
inhaled anticholinergics, long acting, tiotropium
As Treatment, Chronic
Is better Than
long acting beta2-agonists, salmeterol
To reduce number of moderate or seve exarcerbations at 1 year: 0.64 tiotropium VS 0.72 salmeterol. the incidence of serious adverse events was similar.