chronic obstructive pulmonary disease, stable, early stage
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2017 Sep 07;377(10):923-935 Randomized Controlled Trial, Multicenter Study
IN chronic obstructive pulmonary disease, stable, early stage The Use of
inhaled anticholinergics, long acting, tiotropium
As Treatment, Chronic
Is better Than
placebo
To slightly improve at 2 years the FEV1 (mean difference 71 to 133 ml after bronchodilator use) and slightly reduce the decline of FEV1 after bronchodilator use (29 ml/year tiotrop VS 51 ml/year placebo)