chronic obstructive pulmonary disease, emphysema
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2003 May 22;348(21):2059-73 Randomized Controlled Trial
IN chronic obstructive pulmonary disease, emphysema The Use of
lung-volume-reduction surgery
As Treatment, Chronic
Is equal Than
medical therapy only
To reduce mortality (overall 11% per year in both treatment groups) and improve exercise capacity (15% in intv. VS 3% in ctrl.). Mortality was reduced in patients with predominantly upper-lobe emphysema and low exercise capacity, but increased in the rest.
Chest. 2005 Nov;128(5):3489-99 Randomized Controlled Trial, Multicenter Study
IN chronic obstructive pulmonary disease, emphysema The Use of
lung-volume-reduction surgery
As Treatment, Chronic
Is worse Than
physical training alone
To perioperative and at 1 year mortality risk: 7/53 patients death in the surgery group VS 1/53 patients in control (p non significant). Health status and FEV1 were improved after surgery at 1 year.