cancer, prostate, primary prevention in healthy men
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2003 Jul 17;349(3):215-24 Randomized Controlled Trial, Multicenter Study
IN cancer, prostate, primary prevention in healthy men The Use of
finasteride
As Prevention, Primary
Is better Than
placebo
To prevent development of prostate cancer (2,63%/year in intv VS 3,48%/year), benign prostatic hyperplasia (5,2% VS 8,7%) and have less urinary symptoms. But intv group had more sexual dysfunction and prostatic cancers were high grade more freq(6,4% vs 5,1%)