cancer, prostate, early non-metastatic
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2005 May 12;352(19):1977-84 Randomized Controlled Trial, Multicenter Study
IN cancer, prostate, early non-metastatic The Use of
radical prostatectomy
As Treatment, Acute
Is better Than
watchful waiting
To decrease - at 8 years - metatasis development, local progression, death due to prostate cancer (8.6% with surgery VS 14.4% waiting) and total mortality (24% with surgery VS 30.5% waiting)
Ann Intern Med. 2008 Mar 18;148(6):435-48 Systematic Review
IN cancer, prostate, early non-metastatic The Use of
radical prostatectomy
As Treatment, Acute
Is better Than
watchful waiting or external-beam radiation
To reduced at 10 years all-cause mortality (24% prostatectomy vs. 30% wacthful) or reduce at 5 years cancer recurrence
N Engl J Med. 2016 Oct 13;375(15):1425-1437 Randomized Controlled Trial, Multicenter Study
IN cancer, prostate, early non-metastatic The Use of
active monitoring
As Treatment, Chronic
Is better Than
radical prostatectomy, or external-beam radiotherapy
To preserve sexual, urinary and bowel functions: sexual and urinary function declined gradually. Prostatectomy was the worst on sexual function and urinary continence. Radiotherapy reduced sexual and bowel functions but did not impact continency
N Engl J Med. 2016 Oct 13;375(15):1415-1424 Randomized Controlled Trial, Multicenter Study
IN cancer, prostate, early non-metastatic The Use of
active monitoring only
As Treatment, Chronic
Is equal Than
radical prostatectomy, or external-beam radiotherapy
To change overral mortality and prostate-cancer-specific deaths at 10 years follow-up: 1.5/1000 persons-year active monitoring VS 1/1000 prostatectomy VS 0.7/1000 radiotherapy. More disease progression and metastases in monitoring only