cancer, colorectal, metastatic
DISEASE INTERVENTION COMPARISON RESULTS
Arch Surg. 2005 Feb;140(2):183-9 Cohorts
IN cancer, colorectal, metastatic The Use of
prognostic factors: Dukes stage, number of metastases, carcino-embryonic antigen, alkaline phosphatase, and albumin
As Prognostic Item
Is good Than
-
To derive prognoses groups having different survival at 5 years: poor (0% survival), moderate (20% survival), good (62,5% survival)
N Engl J Med. 2004 Jun 3;350(23):2335-42 Randomized Controlled Trial, Multicenter Study, Clinical Trial, Phase III
IN cancer, colorectal, metastatic The Use of
monoclonal antibodies against vascular endothelial growth factor, bevacizumab, added to chemotherapy
As Treatment, Acute
Is better Than
chemotherapy alone (IFL: irinotecan, fluorouracil, and leucovorin in all cases)
To increase the rate of response (45% in intv VS 35% in ctrl) and median survival (20.3 months in intv. VS 15.6 months in ctrl.). Bevacizumab was associated with arterial hypertension (11%)
Lancet. 1997 Sep 6;350(9079):681-6 Randomized Controlled Trial
IN cancer, colorectal, metastatic The Use of
quimioterapia cronomodulada, fluorouracilo, oxiplatino
As Treatment, Acute
Is Than
To
Cancer. 1996 Oct 15;78(8):1639-45 Meta-Analysis
IN cancer, colorectal, metastatic The Use of
quimioterapia regional hepática, vía arterial
As Treatment, Acute
Is Than
To
Lancet. 2000 Jul 29;356(9227):373-78 Meta-Analysis
IN cancer, colorectal, metastatic The Use of
quimioterapia, fluorouracilo, infusión continua
As Treatment, Acute
Is Than
To
Lancet. 2002 May 4;359(9317):1555-63 Randomized Controlled Trial, Multicenter Study
IN cancer, colorectal, metastatic The Use of
quimioterapia, fluorouracilo, infusión continua, raltitrexed
As Treatment, Acute
Is Than
To
BMJ. 2000 Sept 2;321(7260):531-5 Meta-Analysis
IN cancer, colorectal, metastatic The Use of
quimioterapia, quimioterapia regional hepática, fluorouracilo, irinotecan
As Treatment, Acute
Is Than
To
Health Technol Assess. 2001;5(25):1-128 Review, Academic
IN cancer, colorectal, metastatic The Use of
chemotherapy combining irinotecan or oxiplatin with fluorouracil and folinic acid
As Treatment, Acute, First-line
Is better Than
chemotherapy with fluorouracil and folinic acid alone
To extend both median progression-free and overall survival by a few (2-3) months.