cancer, brain, glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma), low-grade
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2016 Apr 7;374(14):1344-55 Randomized Controlled Trial, Multicenter Study
IN cancer, brain, glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma), low-grade The Use of
radiation therapy followed by six cycles of combination chemotherapy: procarbazine, lomustine (also called CCNU), and vincristine, all at the time of initial diagnosis
As Treatment, Acute
Is better Than
radiation therapy alone
To improve median overall survival (13.3 years radiation+chemo VS 7.8 years radiation only). Overall survival at 10 years: 60% combined Tt VS 40% radiation only