bronchiolitis, acute, viral, infants
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2009 May 14;360(20):2079-89 Randomized Controlled Trial, Multicenter Study
IN bronchiolitis, acute, viral, infants The Use of
combination of nebulized epinephrine (3 ml of epinephrine in a 1:1000 solution, x2 days) and oral dexamethasone (1.0 mg/Kg 1st day and 0.6 mg/Kg for 5 days)
As Treatment, Acute
Is better Than
placebo, or any of both treatment alone
To reduce need for hospital admission: 17% combined Tt VS 26% placebo
Cochrane Database Syst Rev. 2008;(4):CD006458 Systematic Review, Cochrane Review
IN bronchiolitis, acute, viral, infants The Use of
nebulized hypertonic 3% saline solution
As Treatment, Acute
Is better Than
nebulized isotonic 0,9% saline solution
To reduce mean length of hospital stay (-0.94 days) and improve clinical score.
JAMA Pediatr. 2014 Jul 1;168(7):657-63 Randomized Controlled Trial
IN bronchiolitis, acute, viral, infants The Use of
nebulized hypertonic 3% saline solution (plus albuterol)
As Treatment, Acute
Is better Than
nebulized 0.9% normal saline solution (plus albuterol)
To reduce admissions to hospital: 29% hypertonic VS 43% normal saline.