asthma, persistent, mild
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2005 Apr 14;352(15):1519-28 Randomized Controlled Trial
IN asthma, persistent, mild The Use of
as-needed corticosteroids, intermittent short-courses of inhaled or oral corticosteroids
As Treatment, Chronic
Is equal Than
as-needed inhaled corticoisteroids added to either daily inhaled corticosteroids or oral zafirlukast
To improve rate of asthma exacerbations or quality of life, taking much lesser doses of corticosteroids
Cochrane Database Syst Rev. 2013;2:CD009611 Systematic Review, Cochrane Review
IN asthma, persistent, mild The Use of
intermitent, as needed inhaled corticosteroids
As Treatment, Chronic
Is equal Than
daily inhaled corticosteroids, continuous
To modify the number of exacerbations, adverse effects, hospitalisations, emergency department visits or quality of life. In children, daily corticosteroid were associated with some lesser growth
N Engl J Med. 2011 May 5;364(18):1695-707 Randomized Controlled Trial
IN asthma, persistent, mild The Use of
leukotriene antagonists
As Treatment, Chronic
Is equal Than
inhaled glucocorticoid for first-line asthma-controller therapy, or a long-acting beta(2)-agonist as add-on therapy
To improve asthma-related quality of life at 2 months (MiniAQLQ score improvement of about 1 point) but not at 2 years (-0.11 points for leukotriene antag).
N Engl J Med. 2007 May 17;356(20):2027-39 Randomized Controlled Trial, Multicenter Study
IN asthma, persistent, mild The Use of
once daily inhaled corticosteroids
As Treatment, Chronic
Is better Than
leukotriene antagonist, once daily monlelukast
To reduce, at 4 months, treatment failure (20% inhaled corticoids VS 30% montelukast)