asthma, persistent despite treatment with inhaled glucocorticoids and long-acting beta-agonists
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2012 Sep 2. [Epub ahead of print] Randomized Controlled Trial, Multicenter Study
IN asthma, persistent despite treatment with inhaled glucocorticoids and long-acting beta-agonists The Use of
inhaled long-acting anticholinergics, tiotropium
As Treatment, Chronic
Is better Than
placebo
To increase time to the first severe exacerbation (282 days vs. 226 days), and reduce risk of severe exacerbation (HR, 0.79). No deaths. Patients with cardiac disease were excluded: safety of tiotropium there?