anticoagulants, vitamin K antagonists, monitoring
DISEASE INTERVENTION COMPARISON RESULTS
Lancet. 2006 Feb 4;367(9508):404-11 Meta-Analysis
IN anticoagulants, vitamin K antagonists, monitoring The Use of
patient self-monitoring of anticoagulation
As Dosage Scheme
Is better Than
standard monitoring by a health professional
To reduce thromboembolic events (OR 0.45, NNT aprox 38), all-cause mortality (OR 0.61, NNT aprox 67), and major haemorrhage (OR 0.65, NNT aprox 67)
Ann Intern Med. 2011 Apr 5;154(7):472-82 Meta-Analysis
IN anticoagulants, vitamin K antagonists, monitoring The Use of
patient self-monitoring of anticoagulation, with or without self-management
As Dosage Scheme
Is better Than
usual care and monitoring by a health professional
To reduce thromboembolic events (OR 0.58) and total mortality (OR 0.74), with no excess of major bleedings (OR 0.89)
BMJ. 2002 Nov 9;325(7372):1073-5 Descriptive
IN anticoagulants, vitamin K antagonists, monitoring The Use of
INR values in excess
As Prognostic Item
Is useful Than
No control
To hight INRs are associated with an excess mortality. With an increase of 1 unit of INR above 2.5, the risks of death from cerebral bleeding (149 deaths / 42 451 patients) and from any cause were about doubled