anticoagulants, vitamin K antagonists, excessive anticoagulation, without major bleeding
DISEASE INTERVENTION COMPARISON RESULTS
Ann Intern Med. 2009 Mar 3;150(5):293-300 Randomized Controlled Trial, Multicenter Study
IN anticoagulants, vitamin K antagonists, excessive anticoagulation, without major bleeding The Use of
low dose oral vitamin K (1.25mg)
As Treatment, Acute
Is equal Than
placebo
To reduce any bleeding (15.8% vit VS 16.3% placebo) or major bleedings (2.5 % vit K VS 1.1% placebo)
Arch Intern Med. 2003 Nov 10;163(20):2469-73 Randomized Controlled Trial
IN anticoagulants, vitamin K antagonists, excessive anticoagulation, without major bleeding The Use of
oral vitamin K1 (2.5mg if INR 6-10, 5mg if INR > 10)
As Treatment, Acute
Is equal Than
intravenous vitamin K1 (0.5mg if INR 6-10, 1mg if INR > 10)
To correct INR: response to intravenous phytonadione was more rapid at 6 and 12 hours, but at 24 hours INR values were similar for both groups and more patients in the IV group were overcorrected (INR < 2: 8.7% in PO group VS 29% in IV group)