amyloidosis, AA type, associated to chronic inflammatory disorders
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2007 Jun 7;356(23):2361-71 Cohorts
IN amyloidosis, AA type, associated to chronic inflammatory disorders The Use of
serum amyloid A (SAA) concentration during follow-up
As Prognostic Item
Is useful Than
-
To predict long term evolution: renal dysfunction - which was the predominant disease manifestation - and mortality if SAA was low-normal (< 4 mg)
N Engl J Med. 2007 Jun 7;356(23):2349-60 Randomized Controlled Trial
IN amyloidosis, AA type, associated to chronic inflammatory disorders The Use of
eprodisate, interfere with interactions between amyloidogenic proteins and glycosaminoglycans
As Treatment, Chronic
Is better Than
placebo
To reduce at 2 years progression of renal failure: 27% eprodisate VS 40% placebo.