depression, unipolar, refractory
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2006 Mar 23;354(12):1231-42 Randomized Controlled Trial, Multicenter Study
IN depression, unipolar, refractory The Use of
bupropion-SR, sertraline, or venlafaxine-XR
As Treatment, Chronic
Is equal Than
each other
To improve depression after failure of SSRI (no remission or intolerance) : about 25% patients responded with all 3 treatments
Am J Psychiatry. 2007 May;164(5):739-52 Randomized Controlled Trial, Multicenter Study
IN depression, unipolar, refractory The Use of
cognitive therapy
As Treatment, Chronic
Is equal Than
pharmacologic treatment : sustained-release bupropion, buspirone or associating a second antidepressant
To improve depression after SSRI failure (no response or intolerance) : equal number of responders. Pharmacologic augmentation was more rapidly effective but has more adverse effects
Am J Psychiatry. 2011 Jul;168(7):681-8 Systematic Review
IN depression, unipolar, refractory, older patients The Use of
lithium, extended-release venlafaxine and selegiline
As Treatment, Chronic
Is better Than
placebo or other therapeutic options
To improve clinical response : overall 52% of aptients responded